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张伟杰
2017-12-05 19:44  点击:[]

张伟杰(1975年8月-),亚慱体育app下载(职称:教授),硕士研究生导师。1997年本科毕业于张家口医学院医学系临床医学专业,2006年在华中农业大学植物遗传育种专业获农学硕士学位,2009年在中国科学院海洋研究所海洋药物学专业获理学博士学位。目前主要承担药剂学、现代药剂学、人体解剖生理学、细胞培养技术等课程教学和从事生物医学材料和药物制剂等方面的研究工作,先后承担国家自然科学基金、浙江省科技攻关重大专项、甘肃省自然基金等纵横向研究课题10余项,公开发表学术论文30余篇,其中SCI/EI收录17篇,申请或授权发明专利10余项。

近五年主持科研项目立项情况:

1、归芪多糖基水凝胶的制备及其与3D喷墨打印的血管内皮细胞互作机理研究、国家自然科学基金委,2016/1-2019/12,44.36万元,主持。

2、当归多糖促进组织工程支架血管化及作用机制研究,甘肃省科技厅,2014/9-2017/9,3万元,主持。

3、靶向EGFR的重组蛋白光敏剂的构建和作用机理研究,甘肃省教育厅,2012/8-2015/8,4万元,主持。

4、WT1DNA肿瘤疫苗的制备和免疫原性研究,甘肃省科技厅,2010/6-2012/6,2万元,主持。

5、头足类活性物质的功能特性及产业化开发,浙江省科技厅,2010/01-2013/9,130万元,子项目主持。

6、复合胶原蛋白合成工艺和促生长机理研究,兰州理工大学,2009/09-2012/9,3万元,,主持。

近5年代表性成果:

代表性论文:

1、Xiuying Pu, Xiaoyue Li, Weijie Zhang*, Xiaochun Wang, Haibing Li, Haowen Li, and Wenjun Xu. Preparation of chitosan/safflower and ligusticum wallichii polysaccharides hydrogel for potential application in drug delivery and tissue engineering. J. Mater. Res. , DOI: 10.1557/jmr.2017.255.

2、Weijie Zhang,Lei Zhao,Jiangzhong Ma, Chenguang Yang, Xiuying Pu, Yonggang Wang, Fen Ran, Yanling Wang, Hui Ma. A kind of injectable Angelica sinensis polysaccharide (ASP) / hydroxyapatite (HAp) material for bone tissue engineering promoting vascularization, hematopoiesis and osteogenesis in mice. International Journal of Polymeric Materials and Polymeric Biomaterials, DOI :10.1080/00914037.2017.1320656

3、Weijie Zhang,Lei Zhao,Jiangzhong Ma,Xiaochun Wang, Yonggang Wang, Fen Ran, Yanling Wang, Hui Ma, and Shujing Yu. Electrospinning of Fucoidan/Chitosan/Poly(vinyl alcohol) Scaffolds for Vascular Tissue Engineering. Fibers and Polymers,2017,18(5): 922-932

4、Weijie Zhang, Xiaochun Wang, Jianzhong Ma, Lei Zhao, Chenguang Yang, Keyi Wang, Xiuying Pu, Yonggang Wang, Fen Ran, Yanling Wang, Shujing Yu, Hui Ma. Preparation of chitosan/pumpkin polysaccharide hydrogel for potential application in drug delivery and tissue engineering. J Porous Mater. 2017, 24:497–506.

5、Zhang Weijie, Chen Zhuo, Ma Sujuan, Wang Yonggang, Zhang Fei, Wang Keyi, Yang Chenguang, Pu Xiuying, Ma Jianzhong, Wang Yuli, Leng Feifan, Ran Fen, Kuang Yanbei. Cistanche polysaccharide (CDPS)/polylactic acid (PLA) scaffolds based coaxial electrospinning for vascular tissue engineering, International Journal of Polymeric Materials and Polymeric Biomaterials, 2016; 65:1, 38-46.

6、Weijie Zhang, Dawei Hua, Sujuan Ma, Zhuo chen, Yonggang Wang, Fei Zhang, Feifan Leng, Xiuying Pu. Preliminary study for vascular tissue engineering by electrospinning Angelica polysaccharide (ASP)/PLA microfibrous scaffolds. International Journal of Polymeric Materials and Polymeric Biomaterials, 2014; 63(13): 672-679.

7、Zhang Weijie, Wang Peng, Wang Yonggang, Fu Wandong, Pu Xiuying, Zhang Fei, Hua Dawei, Ma Sujuan1, Chenzhuo, Wang Minggang. Preparation and Characterization of Porous Chuanxiong Polysaccharide/Squid Skin Collagen Composite Scaffolds, Journal of Biobased Materials and Bioenergy. 2013; 7(3): 323-330.

8、Zhang W, Guan X, Yang Y, etc. Biosynthesis fluorescent allophycocyanin alpha-subunits by autocatalyzing in E. coli Biotechnol Appl Biochem. 2009, 52(2):135-40.

9、X.Y. Guan, W.J. Zhang, X.W. Zhang, Y.X. Li, J.F. Wang, H.Z. Lin, X.X. Tang and S. Qin, A potent anti-oxidant property: fluorescent recombinant α-phycocyanin of Spirulina. J Appl Microbiol. 2009; 106: 1093–1100.

10、Yang Y, Ge B, Guan X, Zhang W, Qin S, Combinational biosynthesis of a fluorescent cyanobacterial holo-alpha-allophycocyanin in Escherichia coli. Biotechnol Lett. 2008; 30:1001-4.

11、Liu Shaofang, Chen Huaxin, Qin Song, Zhang Weijie, Guan Xiangyu, Lu Yandu. Highly soluble and stable recombinant holo-phycocyanin alpha subunit expressed in Escherichia coli, Biochemical Engineering Journal, 2009, 48(1): 58-64.

12、Wang, Y., Leng, F., Liu, X., Zhang, W., & Yang, M.. Optimization of microwave-assisted extraction of water-soluble polysaccharides from piteguo fruit by response surface methodology. Food Science & Technology Research, 2014; 20(4), 755-764.

13、Pu X, Fan W, Yu S, Li Y, Ma X, Liu L, Ren J, Zhang W. Polysaccharides from Angelica and Astragalus exert hepatoprotective effects against carbon-tetrachloride-induced intoxication in mice. Can J Physiol Pharmacol. 2015; 93(1):39-43.

14、Wang, Y., Wang, F., Ma, X., Sun, S., Leng, F., & Zhang, W., et al. Extraction, purification, characterization and antioxidant activity of polysaccharides from piteguo fruit. Industrial Crops & Products, 2015; 77(10), 467-475.

15、Pu X, Ma X, Liu L, Ren J, Li H, Li X, Yu S, Zhang W, Fan W, Structural characterization and antioxidant activity in vitro of polysaccharides from angelica and astragalus. Carbohydr Polym. 2016; 137:154-64.

16、Ran, F., Shen, K., Tan, Y., Peng, B., Chen, S., Zhang, W. Activated hierarchical porous carbon as electrode membrane accommodated with triblock copolymer for supercapacitors. Journal of Membrane Science, 2016; 514, 366-375.

17、Ran, F., Song, H., Ma, L., Niu, X., Wu, J., Zhang, W.. Fabrication and cytocompatibility evaluation for blood-compatible polyethersulfone membrane modified by a synthesized poly (vinyl pyrrolidone)- block -poly (acrylate- graft -poly(methyl methacrylate))- block -poly-(vinyl pyrrolidone). Polymers for Advanced Technologies, 2016; 27(5), 591–596.

授权或公告的专利:

已授权的专利:

1、张伟杰, 张飞, 付万冬, 王永刚, 杨明俊. 脱色鱿鱼皮胶原蛋白的制备方法, 中国, ZL201210013039.8.

2、张伟杰, 王永刚, 马建忠, 冷非凡, 蒲秀瑛, 陈卓, 张庭瑞. 靶向EGFR的重组蛋白光敏剂及其制备方法, 中国, ZL201410018512.0.

3、王永刚, 张伟杰, 马建忠, 冷非凡, 蒲秀瑛, 陈卓, 张庭瑞. 靶向重组蛋白光敏剂及其制备方法, 中国, ZL201410018463.0

4、秦松, 丁玲, 张伟杰, 李富超, 哈特穆特·拉赤. (3aR,5R,11bR)-3,3a,5,11b-四氢-7-羟基-5-甲基-2H-呋[3,2-b]萘并[2,3-d]吡喃-2,6,11-三酮的应用, 中国, ZL200810017159.9.

5、丁玲, 秦松, 李富超, 张伟杰, 哈特穆特·拉赤. 一种查尔霉素化合物及其制备和应用, 中国, ZL200810138336.9.

6、张伟杰,鲍慧 ,马建忠等,具有抗氧化功效的海带多糖活性面膜液及制备方法,中国,CN107115229A.

7、张伟杰,夏韵雅,马建忠等,一种多功能多糖水凝胶的制备方法及用途,中国,CN107189081A.

8、张伟杰,闫金鑫,马建忠等,天花粉多糖/黄芪多糖复合水凝胶的制备方法及用途,中国,CN107033370A.

9、张伟杰,孙萌,马建忠等,金银花/薄荷复合多糖水凝胶的制备方法及用途,中国,CN107057086A.

10、张伟杰,王小春,马建忠等,用于3D打印的多功能水凝胶的制备方法,中国,CN105770998A.

11、张伟杰,王小春,马建忠等,具有降糖作用的南瓜多糖复合水凝胶的制备方法,中国,CN106214623A.


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